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  • Title: Omega-3 fatty acids suppress growth of SW620 human colon cancer xenografts in nude mice.
    Author: Bathen TF, Holmgren K, Lundemo AG, Hjelstuen MH, Krokan HE, Gribbestad IS, Schønberg SA.
    Journal: Anticancer Res; 2008; 28(6A):3717-23. PubMed ID: 19189655.
    Abstract:
    AIM: The purpose of this study was to examine the influence of fish oil on growth of colon cancer in nude mice. MATERIALS AND METHODS: Xenografts were initiated in mice receiving a standard diet or diets modified with corn or fish oil. After 3 weeks, mice were sacrificed, tumours were removed and processed for lipid analysis, histopathology and high resolution magic angle spinning magnetic resonance spectroscopy. RESULTS: Diet modified with fish oil suppressed tumour growth. Xenografts from mice receiving fish oil had higher levels of omega-3 polyunsaturated fatty acids (PUFAs) with concomitant reduced levels of omega-6 PUFAs. Furthermore, these xenografts had significantly lower levels of phosphocholine. Overall the results indicated less aggressive tumour growth in mice receiving a fish oil diet.
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