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  • Title: Utilization of V kappa families and V kappa exons. Implications for the available B cell repertoire.
    Author: Kalled SL, Brodeur PH.
    Journal: J Immunol; 1991 Nov 01; 147(9):3194-200. PubMed ID: 1919010.
    Abstract:
    A molecular cloning approach was used to determine the relative utilization of 2 individual V kappa 21 genes, 13 V kappa gene families, and the 4 functional J kappa gene segments among splenic B cells of nonimmunized BALB/c mice. Based on the observed frequency of individual V kappa gene expression, we estimate that the mouse genome encodes 150 to 180 functional V kappa genes, and we suggest that most functional V kappa exons are expressed at comparable frequencies in the preimmune antibody repertoire. In contrast, clear differences in J kappa segment utilization were observed, J kappa 4 being consistently underrepresented with respect to the other J kappa segments.
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