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  • Title: Neopyrrolomycins with broad spectrum antibacterial activity.
    Author: Hopp DC, Rhea J, Jacobsen D, Romari K, Smith C, Rabenstein J, Irigoyen M, Clarke M, Francis L, Luche M, Carr GJ, Mocek U.
    Journal: J Nat Prod; 2009 Feb 27; 72(2):276-9. PubMed ID: 19191549.
    Abstract:
    Three new antibiotics, neopyrrolomycins B (1), C (2), and D (3), with potent activity against Gram-positive pathogens were discovered. They exhibited MIC values < 1 microg/mL versus a number of resistant strains. The compounds were obtained from the ethyl acetate extracts of a Streptomyces sp. after purification by column chromatography and RP-HPLC. Their structures were elucidated using X-ray crystallography (1) and NMR spectroscopy (2 and 3).
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