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  • Title: The accuracy of intraoperative frozen section of the inguinal sentinel lymph node in vulvar cancer.
    Author: Brunner AH, Polterauer S, Tempfer C, Joura E, Reinthaller A, Horvat R, Hefler L.
    Journal: Anticancer Res; 2008; 28(6B):4091-4. PubMed ID: 19192665.
    Abstract:
    BACKGROUND: Limited data are available for the accuracy of intraoperative frozen section analysis of inguinal sentinel lymph node in patients with vulvar cancer. PATIENTS AND METHODS: Forty-four patients with vulvar cancer treated with separate incisions for inguinal sentinel lymph node dissection between 2001 and 2007 were evaluated in the present study. RESULTS: Out of 44 patients, 3 had a false-negative intraoperative frozen section result due to micrometastasis. No false-positive result of the intraoperative frozen section analysis was obtained. We identified two studies, which exclusively examined the false-negative rate of frozen section analysis of the sentinel lymph node. Data of these 3 studies were pooled, yielding an overall underdiagnosis of frozen section analysis in 6/128 (4.7%) patients, resulting in sensitivity, specificity and positive and negative predictive values of 88.5%, 100%, 100% and 93.2%, respectively. CONCLUSION: Intraoperative frozen section analysis of the inguinal sentinel lymph nodes exhibits good sensitivity/specificity characteristics for the assessment of inguinal lymph node involvement in patients with vulvar cancer.
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