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  • Title: Structure-activity relationship of new anti-hepatitis C virus agents: heterobicycle-coumarin conjugates.
    Author: Neyts J, De Clercq E, Singha R, Chang YH, Das AR, Chakraborty SK, Hong SC, Tsay SC, Hsu MH, Hwu JR.
    Journal: J Med Chem; 2009 Mar 12; 52(5):1486-90. PubMed ID: 19193060.
    Abstract:
    For establishment of the structure-activity relationship, 19 heterobicycle-coumarin conjugated compounds with the -SCH(2)- linker were synthesized and found to possess significant antiviral activities. Prominent examples included imidazopyridine-coumarin 12c, purine-coumarin 12d, and benzoxazole-coumarin 14c, which inhibited HCV replication at an EC(50) of 6.8, 2.0, and 12 microM, respectively. The heteroatoms in bicycles and the substituent effect on coumarin played essential roles.
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