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  • Title: Influences of hypothermia on the cortical blood supply by laser speckle imaging.
    Author: Li M, Miao P, Yu J, Qiu Y, Zhu Y, Tong S.
    Journal: IEEE Trans Neural Syst Rehabil Eng; 2009 Apr; 17(2):128-34. PubMed ID: 19193518.
    Abstract:
    Induced hypothermia has been broadly applied in neurological intensive care unit (NICU). Meanwhile, accidental hypothermia is also a threatening condition in daily life. It is meaningful to investigate the influences of temperature change on the cerebral blood flow (CBF). In the present study, temporal laser speckle image contrast analysis (tLASCA) was implemented to study the relative CBF change in cerebral artery, vein and capillary level under mild (35 degrees C) and moderate (32 degrees C) hypothermia. Twelve male Sprague-Dawley rats (300 +/-50 g) were anesthetized with sodium pentobarbital and randomly assigned to mild and moderate hypothermia groups (n=9 each). Laser speckle imaging (LSI) trials were acquired from baseline (37 degrees C), hypothermia (35 degrees C or 32 degrees C), and post-rewarming (37 degrees C) phases. In the mild group, mean CBF in different vessels all increased throughout the hypothermic and post-rewarming phases. On the contrary, mean CBF reduced by 10%-20% at 32 degrees C and returned to approximately 95% of the baseline level during the post-rewarming session in the moderate group. Besides, in the moderate group, a CBF rebound in vein was found in the post-rewarming phase. Our results suggested that the CBF changed differently between mild and moderate hypothermia, which may be worth for further study in clinic. And we demonstrated LSI as a promising method to achieve high spatiotemporal resolution CBF change with minimal invasion.
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