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  • Title: Crystallization and preliminary X-ray diffraction analysis of human IL-22 bound to its soluble decoy receptor IL-22BP.
    Author: Watanabe L, de Moura PR, Nascimento AS, Colau D, Dumoutier L, Renauld JC, Polikarpov I.
    Journal: Acta Crystallogr Sect F Struct Biol Cryst Commun; 2009 Feb 01; 65(Pt 2):102-4. PubMed ID: 19193995.
    Abstract:
    Interleukin-22 (IL-22) is a pleiotropic cytokine that is involved in inflammatory responses. Human IL-22 was incubated with its soluble decoy receptor IL-22BP (IL-22 binding protein) and the IL-22-IL-22BP complex was crystallized in hanging drops using the vapour-diffusion method. Suitable crystals were obtained from polyethylene glycol solutions and diffraction data were collected to 2.75 A resolution. The crystal belonged to the tetragonal space group P4(1), with unit-cell parameters a = b = 67.9, c = 172.5 A, and contained two IL-22-IL-22BP complexes per asymmetric unit.
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