These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Reversed-phase high performance liquid chromatographic separation of diastereomers of beta-amino alcohols and microwave assisted synthesis of Marfey's reagent, its chiral variants and diastereomers.
    Author: Bhushan R, Kumar R.
    Journal: J Chromatogr A; 2009 Mar 20; 1216(12):2592-6. PubMed ID: 19195660.
    Abstract:
    Ten chiral derivatizing reagents (CDRs) were synthesized by replacing the L-Ala-NH(2) moiety in Marfey's reagent (MR) by seven L-amino acid amides and three L-amino acids employing microwave irradiation (MW) and were characterized. Ten racemic amino alcohols were derivatized with these CDRs under MW. The diastereomers were separated on a reversed-phase C(18) column using binary mixtures of acetonitrile with aqueous trifluoroacetic acid (TFA) and triethylammonium phosphate buffer (TEAP). In general, amino acid variants of MR provided better separation of diastereomers in comparison to amino acid amide variants. The method was also found successful for the separation of 20 diastereomers from a mixture.
    [Abstract] [Full Text] [Related] [New Search]