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  • Title: Electronic detection of DNA mutation based on strand exchange reaction.
    Author: Watanabe M, Kumamoto S, Nakamaura M, Yamana K.
    Journal: Bioorg Med Chem; 2009 Feb 15; 17(4):1494-7. PubMed ID: 19195899.
    Abstract:
    A new approach to electronic detection of a single base mismatch is described. The assay involves the electrochemical measurements of DNA strand exchange reactions (SERs) between electrode-bound redox-modified DNA duplex and target DNA, where the sequence of redox-modified DNA is exchangeable to that of the target DNA. The presence of a single base mismatch can be determined from the slower SER rates compared with fully matched DNA.
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