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  • Title: Microbial models of mammalian metabolism: fungal metabolism of the diterpene sclareol by Cunninghamella species.
    Author: Kouzi SA, McChesney JD.
    Journal: J Nat Prod; 1991; 54(2):483-90. PubMed ID: 1919591.
    Abstract:
    Microbial metabolism of the diterpene sclareol was studied. Screening studies have shown a number of microorganisms capable of metabolizing sclareol. Preparative scale fermentation with Cunninghamella species NRRL 5695 has resulted in the production of two fungal metabolites that have been characterized as 3 beta-hydroxysclareol and 18-hydroxy-sclareol with the use of 2D nmr techniques. The yield of the two metabolites was improved by utilizing resting-cell suspensions of Cunninghamella species NRRL 5695.
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