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  • Title: [Cholesterol synthesis in the skin of rats with rickets].
    Author: Semenov VL, Datsenko ZM.
    Journal: Ukr Biokhim Zh; 1976; 48(5):645-9. PubMed ID: 191968.
    Abstract:
    The rachitogenic diet causes an inhibition of cholesterol synthesis in rat skin. Intensity of 2-14S-acetate incorporation into cholesterol precursors (matastenol, lathosterol, 7-dehydrocholesterol) and cholesterol drops considerably. UV-irradiation of animals suffering from rachitis intensifies cholesterol synthesis in skin. Simulteneously an increase is detected in the metabolic fund of cholesterol synthesis precursors, including 7-dehydrocholesterol, which is necessary to form antirachitic compounds in the organism.
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