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  • Title: Allantofuranone, a new antifungal antibiotic from Allantophomopsis lycopodina IBWF58B-05A.
    Author: Schüffler A, Kautz D, Liermann JC, Opatz T, Anke T.
    Journal: J Antibiot (Tokyo); 2009 Mar; 62(3):119-21. PubMed ID: 19198630.
    Abstract:
    In a screening for new bioactive compounds, the extract of Allantophomopsis lycopodina strain IBWF58B-05A, an imperfect ascomycete, was found to exhibit strong but rather selective antibiotic activity against Paecilomyces variotii. The bioactivity-guided isolation yielded allantofuranone, a new and uncommon gamma-lactone. This compound showed antifungal activity against P. variotii and Penicillium species. This paper describes the isolation, structure elucidation and biological characteristics of allantofuranone.
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