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  • Title: The role of gram-negative bacteria in healthcare-associated pneumonia.
    Author: Restrepo MI, Anzueto A.
    Journal: Semin Respir Crit Care Med; 2009 Feb; 30(1):61-6. PubMed ID: 19199188.
    Abstract:
    Healthcare-associated pneumonia (HCAP) is a unique entity that differs from community-acquired pneumonia in both bacteriology and outcomes and has similarities to hospital-acquired pneumonia and ventilator-associated pneumonia. HCAP patients are at higher risk of potential multidrug-resistant pathogens, including resistant gram-negative organisms, especially Pseudomonas aeruginosa and acinetobacter spp., but also extended-spectrum beta-lactamases (ESBLs). This manuscript reviews the epidemiology, etiology, and clinical outcomes of hospitalized HCAP patients due to gram-negative bacteria. We will focus our attention on the potential multidrug-resistant pathogens to suggest a new treatment approach for these patients.
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