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  • Title: Engineering bisquinolinium/thiazole orange conjugates for fluorescent sensing of G-quadruplex DNA.
    Author: Yang P, De Cian A, Teulade-Fichou MP, Mergny JL, Monchaud D.
    Journal: Angew Chem Int Ed Engl; 2009; 48(12):2188-91. PubMed ID: 19199323.
    Abstract:
    Lighting up: A G-quadruplex-specific fluorescent probe was designed combining the specificity of the pyridodicarboxamide motif for guanine quadruplexes and the fluorescence properties of thiazole orange. While the assembly of the two partners through a flexible linker leads to a nonselective probe, merging them in a single, rigid scaffold leads to a dye that elicits the properties required for G-quadruplex sensing.
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