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  • Title: Role played by human mannose-binding lectin polymorphisms in pulmonary tuberculosis.
    Author: Capparelli R, Iannaccone M, Palumbo D, Medaglia C, Moscariello E, Russo A, Iannelli D.
    Journal: J Infect Dis; 2009 Mar 01; 199(5):666-72. PubMed ID: 19199550.
    Abstract:
    BACKGROUND: Mannose-binding lectin (MBL) activates the complement system in an antibody-independent manner, enhances complement-mediated phagocytosis, and plays a major role in the regulation of inflammatory cytokine release by monocytes. METHODS: Case patients (277 patients with pulmonary tuberculosis) and control subjects (288 household contacts) were tested by polymerase chain reaction (PCR) for polymorphisms at the promoter and the exon 1 regions of the MBL gene. Diagnosis of pulmonary tuberculosis, based on findings from chest radiography and sputum smear examination, was confirmed by PCR and bacteriological tests. RESULTS: HYA/HYA subjects were protected against tuberculosis (odds ratio [OR], 0.09 [95% confidence interval {CI}], 0.023-0.408; P < 1 X 10 (-6)). LYB/LYD subjects were susceptible to disease (OR, 49 [95% CI, 2.9-812.5]; P < 1 X 10(-6)). CONCLUSIONS: This study supports the conclusion that MBL can protect or predispose the host to tuberculosis, depending on the host's haplotype pair.
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