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  • Title: Estimating the postantibiotic effect: a two-phase mathematical model.
    Author: Brunden MN, Yagi BH, Lajiness MS, Zurenko GE.
    Journal: J Pharmacokinet Biopharm; 1991 Aug; 19(4):457-68. PubMed ID: 1920089.
    Abstract:
    The postantibiotic effect (PAE) is a suppression of bacterial growth that persists after a short exposure to antimicrobials. The active antibiotic delays the resumption of normal growth. This suppression of bacterial growth following antibiotic removal is described by a two-phase model. The quantification of PAE is a function of the model parameters, for which consistent and asymptotically normal estimators are available.
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