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  • Title: Results with early follicular phase recombinant luteinizing hormone supplementation during stimulation for in vitro fertilization.
    Author: Kovacs P, Kovats T, Kaali SG.
    Journal: Fertil Steril; 2010 Feb; 93(2):475-9. PubMed ID: 19200991.
    Abstract:
    OBJECTIVE: To study the effect of early follicular phase recombinant LH supplementation on stimulation outcome among women undergoing IVF using the GnRHa long protocol and recombinant FSH. DESIGN: Randomized, controlled trial. SETTING: Private IVF unit. PATIENT(S): Women under the age of 40 with normal ovarian function undergoing their first or second IVF cycle. INTERVENTION(S): All stimulations followed the standard luteal long GnRHa down-regulation protocol. At suppression, patients in the experimental group received 75 IU of rLH daily for 4 days, and recombinant FSH at a fixed starting dose of 150 IU for the first 5 days was started a day later, on day 2 of rLH. In the control group, patients started rFSH at a fixed dose of 150 IU for the first 5 days at suppression. MAIN OUTCOME MEASURE(S): Baseline, stimulation, embryology parameters, and treatment outcome were compared. Of primary interest, recombinant FSH need during stimulation was assessed. RESULT(S): Stimulation, embryology parameters, and treatment outcome were comparable. The amount of gonadotropins used and medication expense were similar in the two groups. CONCLUSION(S): Early follicular phase recombinant LH supplementation at a daily dose of 75 IU does not improve response to stimulation among normal responder women undergoing IVF.
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