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  • Title: [Crohn's disease during the course of multiple sclerosis: role of interferon-beta therapy].
    Author: Samson M, Audia S, Duchêne C, Perinet I, Bielefeld P, Besancenot JF.
    Journal: Rev Med Interne; 2009 Sep; 30(9):816-9. PubMed ID: 19201069.
    Abstract:
    Interferon-beta (IFN-beta) therapy can trigger immune adverse effects. We report a patient, who was treated for multiple sclerosis (MS) by IFN-beta during 3 years before developing a severe colitis due to Crohn's disease (CD). Neurological manifestations may occur in CD but rarely mimic MS. This report's points highlight the possible association of MS and CD, where IFN-beta therapy probably unmasked CD. Indeed, similar cases of CD flares have been reported after IFN-alpha therapy for chronic C hepatitis.
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