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  • Title: Effect of cyclic adenosine monophosphate on renal function and renin secretion.
    Author: Gaál K, Forgács I.
    Journal: Acta Physiol Acad Sci Hung; 1975; 46(1):9-18. PubMed ID: 192043.
    Abstract:
    The effect of cAMP, infused into the renal artery, on renal function and on the release of renin was studied in dogs displaying a normal serum Na level. Intrarenal infusion of 1 mg per kg per minute of cAMP caused a significant increase in RBF, dilatation of the efferent arterioles, the redistribution of renal blood flow and a significant increase in tubular Na-reabsorption. The antidiuretic action of cAMP is due partly to a hemodynamic and partly to a direct tubular effect. Decreased renin secretion was explained by the Na-load on the macula densa segment, being decreased by the intrarenal shifting of renal blood flow and with an eventual decomposition of cAMP.
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