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  • Title: High-resolution computed tomographic imaging of airways in sarcoidosis patients with airflow obstruction.
    Author: Naccache JM, Lavolé A, Nunes H, Lamberto C, Letoumelin P, Brauner M, Valeyre D, Brillet PY.
    Journal: J Comput Assist Tomogr; 2008; 32(6):905-12. PubMed ID: 19204453.
    Abstract:
    OBJECTIVE: To investigate airway involvement in patients with pulmonary sarcoidosis and airflow obstruction (AO) using high-resolution computed tomography. METHODS: Forty-two sarcoidosis patients with AO and 42 matched sarcoidosis patients without AO were retrospectively analyzed. High-resolution computed tomographic patterns of airway involvement were bronchial distortion, peribronchovascular thickening, small airway obstruction, and bronchial compression by enlarged lymph nodes. RESULTS: Interobserver agreement was good (kappa > 0.8). High-resolution computed tomographic patterns of airway involvement were found more frequently, scored higher, and were more often multiple (P < 0.05) in patients with AO than those without. Functional improvement under treatment was observed more frequently in patients with predominant peribronchovascular thickening compared with patients with predominant bronchial distortion (P < 0.03). CONCLUSIONS: In pulmonary sarcoidosis patients with AO, high-resolution computed tomography is a reliable tool to identify underlying airways involvements, which are often multiple, and enables prediction of the therapeutic response.
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