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  • Title: Glucose and insulin responses to whole grain breakfasts varying in soluble fiber, beta-glucan: a dose response study in obese women with increased risk for insulin resistance.
    Author: Kim H, Stote KS, Behall KM, Spears K, Vinyard B, Conway JM.
    Journal: Eur J Nutr; 2009 Apr; 48(3):170-5. PubMed ID: 19205780.
    Abstract:
    BACKGROUND: A high intake of whole grains containing soluble fiber has been shown to lower glucose and insulin responses in overweight humans and humans with type 2 diabetes. AIM OF THE STUDY: We investigated the linearity of this response after consumption of 5 breakfast cereal test meals containing wheat and/or barley to provide varying amounts of soluble fiber, beta-glucan (0, 2.5, 5, 7.5 and 10 g). METHODS: Seventeen normoglycemic, obese women at increased risk for insulin resistance consumed 5 test meals within a randomized cross-over design after consuming controlled diets for 2 days. Blood samples for glucose and insulin response were obtained prior to and 30, 60, 120 and 180 min after consuming the test meals. RESULTS: Consumption of 10 g of beta-glucan significantly reduced peak glucose response at 30 min and delayed the rate of glucose response. Area under the curve for 2 h-postprandial glycemic response was not affected by beta-glucan content. However, peak and area under the curve of insulin responses were significantly affected by the beta-glucan amount in an inverse linear relationship. CONCLUSION: These data suggest that acute consumption of 10 g of beta-glucan is able to induce physiologically beneficial effects on postprandial insulin responses in obese women at risk for insulin resistance.
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