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  • Title: FTICR-MS and LC-UV/MS-SPE-NMR applications for the rapid dereplication of a crude extract from the sponge Ianthella flabelliformis.
    Author: Motti CA, Freckelton ML, Tapiolas DM, Willis RH.
    Journal: J Nat Prod; 2009 Feb 27; 72(2):290-4. PubMed ID: 19206511.
    Abstract:
    Dereplication of a methanolic extract of the marine sponge Ianthella flabelliformis using FTICR-MS accurate mass determination and MS(n) techniques enabled rapid and unambiguous detection of a new compound among a plethora of known compounds. Isolation of this compound and the known 19-deoxy analogue using the hyphenated technique LC-UV/MS-SPE-NMR was undertaken, and the structures were confirmed, from a single chromatographic run, as 19-hydroxyaraplysillin-I N(20)-sulfamate (1) and araplysillin-I N(20)-sulfamate (2).
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