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  • Title: Methylation of alpha-amino acids and derivatives using trimethylsilyldiazomethane.
    Author: Leggio A, Liguori A, Perri F, Siciliano C, Viscomi MC.
    Journal: Chem Biol Drug Des; 2009 Mar; 73(3):287-91. PubMed ID: 19207464.
    Abstract:
    A study of the methylation of N-nosyl-alpha-amino acids and derivatives with trimethylsilyldiazomethane is here reported. Trimethylsilyldiazomethane allows the chemo-specific methylation of the carboxyl function of N-nosyl-alpha-amino acids in high yields and purity. This method provides a practical route to N-methyl-alpha-amino acids avoiding the use of the more toxic and explosive diazomethane. This simple and safe methylation methodology of alpha-amino acids and derivatives is not limited to organic synthesis and involves the use of a commercially available reagent as well.
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