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  • Title: Efficacy of combined surgery and antifungal therapies for the management of invasive zygomycoses in patients with haematological malignancies.
    Author: Valentini CG, Candoni A, Fianchi L, Posteraro B, Simeone E, Costa F, Sanguinetti M, Voso MT, Caira M, Fanin R, Pagano L.
    Journal: Mycoses; 2010 Jan; 53(1):89-92. PubMed ID: 19207832.
    Abstract:
    We report two cases of invasive zygomycoses occurring in severely immunocompromised patients with haematological malignancies that were successfully treated with liposomal amphotericin B and surgical debridement, followed by oral administration of posaconazole. These cases demonstrated that an early instituted, aggressive and combined therapeutic approach results in a recovery from invasive fungal infection, without any relapse of infection, thanks to secondary prophylaxis using posaconazole.
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