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  • Title: Laryngeal histoplasmosis in an immunocompetent patient from a non-endemic region: case report.
    Author: Ferrari TC, Soares JM, Salles JM, Handam JS, Azevedo RC, Xavier MA, Faria LC.
    Journal: Mycoses; 2009 Nov; 52(6):539-40. PubMed ID: 19207848.
    Abstract:
    Histoplasma capsulatum infection involving the larynx is a rare manifestation, especially in immunocompetent individuals and a high index of suspicion is needed to establish the diagnosis correctly. We report a case of a 50-year-old Brazilian man who presented with progressive hoarseness and throat pain for 4 months. Laryngoscopy showed a supraglottic vegetant lesion, and the biopsies chronic granulomatous inflammation without any specific agent. A second laryngoscopy with biopsies was performed and after 17 days of incubation in specific medium, H. capsulatum was isolated. The patient was successfully treated with amphotericin B.
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