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  • Title: Two siblings with periodic fever, aphthous stomatitis, pharyngitis, adenitis (PFAPA) syndrome.
    Author: Sampaio IC, Rodrigo MJ, Monteiro Marques JG.
    Journal: Pediatr Infect Dis J; 2009 Mar; 28(3):254-5. PubMed ID: 19209090.
    Abstract:
    PFAPA syndrome (periodic fever, aphthous stomatitis, pharyngitis, adenitis) is a benign sporadic syndrome of unknown cause. We report 2 siblings diagnosed with this syndrome. The second case started crisis simultaneously with recurrence of crisis after a 3-year free interval in her brother. This temporal relation suggests environmental factor acting in genetically predisposed children.
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