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  • Title: Human telomeric DNA sequence-specific cleaving by G-quadruplex formation.
    Author: Xu Y, Suzuki Y, Lönnberg T, Komiyama M.
    Journal: J Am Chem Soc; 2009 Mar 04; 131(8):2871-4. PubMed ID: 19209856.
    Abstract:
    Telomere is an emerging target for the treatment of human cancers. Here, we report a structure-based approach to sequence-specific cleaving of human telomeric DNA by G-quadruplex formation. Oligonucleotide with multiphosphonate [DNA-EDTP.Ce(IV)] at the 5' end binds to human telomere DNA by G-quadruplex formation and causes a sequence-specific strand break. These results provide the first proof of concept for targeting the human telomere DNA based on G-quadruplex formation, and this may serve as a starting point for the design of more efficient telomere sequence-specific cleaving reagents by G-quadruplex formation.
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