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  • Title: Synthesis of 3-aminoisoxazoles via the addition-elimination of amines on 3-bromoisoxazolines.
    Author: Girardin M, Alsabeh PG, Lauzon S, Dolman SJ, Ouellet SG, Hughes G.
    Journal: Org Lett; 2009 Mar 05; 11(5):1159-62. PubMed ID: 19209874.
    Abstract:
    A novel two-step procedure for the synthesis of 3-amino-5-substituted-isoxazoles is described. In the presence of a base, readily available 3-bromoisoxazolines react with amines to afford 3-aminoisoxazolines. An oxidation protocol was developed for these heterocycles to provide 3-aminoisoxazoles in consistently high yield.
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