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  • Title: Synthesis and cytotoxicity screening of piperazine-1-carbodithioate derivatives of 2-substituted quinazolin-4(3H)-ones.
    Author: Cao SL, Guo YW, Wang XB, Zhang M, Feng YP, Jiang YY, Wang Y, Gao Q, Ren J.
    Journal: Arch Pharm (Weinheim); 2009 Mar; 342(3):182-9. PubMed ID: 19212984.
    Abstract:
    A new series of piperazine-1-carbodithioate derivatives of 2-substituted quinazolin-4(3H)-ones were synthesized via a five-steps procedure starting from 2-amino-5-methylbenzoic acid. The cytotoxicity of the resulting compounds against A-549 (human lung cancer), HCT-8 (human colon cancer), HepG2 (human liver cancer), and K562 (human myelogenous leukaemia) cell lines was determined by the MTT assay. Preliminary screening results of these compounds are reported.
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