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  • Title: Highly enantioselective 1,4-addition of diethyl phosphite to enones using a dinuclear Zn catalyst.
    Author: Zhao D, Yuan Y, Chan AS, Wang R.
    Journal: Chemistry; 2009; 15(12):2738-41. PubMed ID: 19212992.
    Abstract:
    Zinc benefits: The first catalytic asymmetric phospha-Michael addition of enones has been developed. Under mild reaction conditions, the gamma-oxo phosphonates could be obtained in high yields (up to 99%) with excellent enantioselectivities (93-99% ee; see scheme). The strategy makes the asymmetric synthesis of biologically important phosphonate compounds more accessible.
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