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  • Title: Potential influences on mathematical difficulties in children and adolescents with neurofibromatosis, type 1.
    Author: Moore BD.
    Journal: Dev Disabil Res Rev; 2009; 15(1):45-51. PubMed ID: 19213018.
    Abstract:
    Neurofibromatosis, type 1 (NF-1) is a common genetic disorder affecting 1 in 3,500-4,000 individuals in the world. Mutations of the NF-1 gene produce a myriad of physical, medical, and psychological manifestations. Although there is a very high degree of variability in the manifestations between individuals with NF-1, the majority of children and adolescents with NF-1 encounter difficulties that negatively impact their educational attainment. NF-1 is associated with a very high incidence of cognitive deficits and learning disability, sometimes including mathematical learning disabilities (MLD). A number of possible inter-related etiologies for MLD specific to children and adolescents with NF-1 are discussed, including the high incidence of attention deficit hyperactivity disorder, visual spatial impairment, morphological and functional brain abnormalities. Thus NF-1 exemplifies the wide ranging sources of potential influences on mathematical learning and MLD.
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