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  • Title: Lupus and T cells.
    Author: La Cava A.
    Journal: Lupus; 2009 Mar; 18(3):196-201. PubMed ID: 19213856.
    Abstract:
    T-cell abnormalities and aberrant T helper cytokine profiles have been implicated in the loss of immune tolerance to nuclear and cytoplasmic antigens and linked to a variety of clinical manifestations in systemic lupus erythematosus (SLE). Here, we review the role of T cells in promoting and maintaining SLE in relation to their cellular and molecular abnormalities and provide an update on recent T cell-targeted therapeutic approaches for the restoration of T cell homeostasis in the disease.
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