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  • Title: Effects of persistent perilymph fistula on the inner ear.
    Author: Kaseki Y, Nakashima T, Fukuta S, Suzuki T, Yanagita N.
    Journal: Laryngoscope; 1991 Oct; 101(10):1085-90. PubMed ID: 1921636.
    Abstract:
    To study the effects of a persistent perilymph fistula on the cochlea, a small cannula was inserted into the scala tympani of the basal turn of cochlea in guinea pigs. A month later, cochlear morphology and blood flow were studied using either histological evaluation or the microsphere surface preparation technique. Some animals showed no cochlear morphologic changes or no cochlear blood-flow reduction, even if tubal patency was maintained and perilymph leakage lasted for 1 month. This suggests that a prolonged perilymph fistula, per se, causes no permanent cochlear damage. However, in some animals, hair cell damage and cochlear blood-flow disorders were observed. These observations and the causes of hearing loss in clinical cases of perilymph fistula were studied.
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