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  • Title: Glycoside modification of oleanolic acid derivatives as a novel class of anti-osteoclast formation agents.
    Author: Li JF, Chen SJ, Zhao Y, Li JX.
    Journal: Carbohydr Res; 2009 Mar 31; 344(5):599-605. PubMed ID: 19217081.
    Abstract:
    Oleanolic acid, a natural product, possesses an anti-osteoclast formation activity. Targeting at discovery of novel and potent anti-bone resorption agents, 22 glycosides of oleanolic acid derivatives (including d-galactopyranosides, d-glucopyranosides, d-xylopyranoses, d-arabopyranoses and d-glycuronic acids) were synthesized at phase-transfer-catalyzed conditions (K(2)CO(3), Bu(4)NBr, CH(2)Cl(2)-H(2)O) and their inhibitory activity on the formation of osteoclast-like multinucleated cells (OCLs) induced by 1alpha, 25-dihydroxy vitamin D(3) was evaluated in a co-culture assay system. The structure-activity relationships of these compounds were also discussed.
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