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  • Title: Is oxidative damage in operation in patients with hereditary spastic paraparesis?
    Author: Gücüyener K, Pinarli FG, Erbaş D, Hasanoğlu A, Serdaroğlu A, Topaloğlu H.
    Journal: Brain Dev; 2010 Feb; 32(2):130-6. PubMed ID: 19217230.
    Abstract:
    Oxidative stress resulting from increased free radical production and/or defects in antioxidant defences may be the cause of various neurodegenerative disorders. In this study, the roles of oxygen free radicals, nitric oxide, superoxide dismutase, vitamin E and vitamin C were investigated in pure and complicated hereditary spastic paraparesis (HSP) patients. The results showed that plasma SOD, vitamin E and nitric oxide levels were significantly low in HSP patients. These findings indicate the influence of oxidative damage in the degenerative process of HSP.
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