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  • Title: Diffusion tensor MRI of the corpus callosum and cognitive function in adults born preterm.
    Author: Kontis D, Catani M, Cuddy M, Walshe M, Nosarti C, Jones D, Wyatt J, Rifkin L, Murray R, Allin M.
    Journal: Neuroreport; 2009 Mar 04; 20(4):424-8. PubMed ID: 19218872.
    Abstract:
    Very preterm birth (before 33 weeks gestation) is associated with the white matter damage, and a common sequel is reduced size and altered shape of the corpus callosum. We used diffusion tensor MRI to assess the corpus callosum in 63 very preterm and 45 term-born young adults. Indices of white matter microstructure [fractional anisotropy (FA) and mean diffusivity (MD)] were obtained for the genu, body and splenium. Very preterm females had higher MD in the genu than term-born females, indicating altered white matter microstructure. This was associated with lower performance IQ. The groups demonstrated different patterns of correlations between verbal learning and tract-specific FA and MD, consistent with the reorganization of white matter structure in adults born very preterm.
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