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  • Title: Cadherin-20 expression by motor neurons is regulated by Sonic hedgehog during spinal cord development.
    Author: Luo J, Ju MJ, Lin J, Yan X, Markus A, Mix E, Rolfs A, Redies C.
    Journal: Neuroreport; 2009 Mar 04; 20(4):365-70. PubMed ID: 19218874.
    Abstract:
    During chicken spinal cord development, cadherin-20 is expressed by motor neurons of the lateral motor column and other cells in the basal and alar plates. To investigate the regulation of cadherin-20 expression, Sonic hedgehog (Shh) signaling was altered in chicken spinal cord and hindbrain by in-vivo electroporation. Our results show that, at an early embryonic stage 12, Shh induces cadherin-20 expression by motor neurons. Later, at stage 24 when the sorting of motor neuron pools begins, cadherin-20 expression is induced in the neural progenitors of the ventricular zone but not in motor neurons. Blockage of Shh signaling inhibits cadherin-20 expression in the motor column. Therefore, cadherin-20 expression in motor neurons is regulated by Shh in a time-dependent manner.
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