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  • Title: Triterpenoid saponins from Anemone flaccida induce apoptosis activity in HeLa cells.
    Author: Han LT, Li J, Huang F, Yu SG, Fang NB.
    Journal: J Asian Nat Prod Res; 2009; 11(2):122-7. PubMed ID: 19219723.
    Abstract:
    Five triterpenoid saponins were isolated from Anemone flaccida Fr. Schmidt. Their structures were identified as glycoside St-I4a (1), glycoside St-J (2), anhuienoside E (3), hederasaponin B (4), and flaccidoside II (5). Compounds 1-2 were isolated from Anemone family for the first time, and compounds 3-4 were isolated from this plant for the first time. The inhibitory effects of saponins on proliferation of HeLa cells were studied by MTT assay, the apoptosis-induction activity was observed by cell-cycle analysis and caspase-3 expression assay. The antitumor activities of the saponins were ranked in the following order: 5 > 3 > 4 > 1 > 2. The data presented here indicated that naturally occurring triterpenoid saponins can be regarded as excellent structures for the potential development of new anticancer agents.
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