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  • Title: Microbial transformation of dehydroandrographolide by Cunninghamella elegans.
    Author: Xin XL, Ma XC, Zhang BJ, Su DH, Wu ZM, Wang XJ, Li XY, Yuan QP.
    Journal: J Asian Nat Prod Res; 2009; 11(2):187-91. PubMed ID: 19219734.
    Abstract:
    The biotransformation of dehydroandrographolide (1) by Cunninghamella elegans was performed and four transformed products were obtained. Based on their extensive spectral data, the structures of these metabolites were identified as 3-oxo-dehydroandrographolide (2), 3-oxo-2beta-hydroxy-dehydroandrographolide (3), 3-oxo-8beta,17alpha-epoxydehydroandrographolide (4), 3,19-dihydroxy-7,11,13-ent-labdatrien-15,16-olide (5), respectively. Among them, products 3-5 are new compounds.
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