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  • Title: Assembly of substituted 3-methyleneisoindolin-1-ones via a CuI/l-proline-catalyzed domino reaction process of 2-bromobenzamides and terminal alkynes.
    Author: Li L, Wang M, Zhang X, Jiang Y, Ma D.
    Journal: Org Lett; 2009 Mar 19; 11(6):1309-12. PubMed ID: 19226134.
    Abstract:
    CuI/l-proline catalyzed coupling of 2-bromobenzamides and terminal alkynes in i-PrOH (or DMF and DMSO) at 85-110 degrees C and subsequent additive cyclization produces substituted 3-methyleneisoindolin-1-ones. Variation of N-substituents, aromatic ring, and methylene part is possible by using suitable starting materials.
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