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  • Title: Sentinel lymph node biopsy after neoadjuvant systemic chemotherapy in patients with breast cancer: a prospective pilot trial.
    Author: Medina-Franco H, Salgado-Nesme N, Zerón-Medina-Cuairán J.
    Journal: Rev Invest Clin; 2008; 60(5):390-4. PubMed ID: 19227436.
    Abstract:
    INTRODUCTION: The feasibility and accuracy of the sentinel lymph node biopsy for patients who have received neoadjuvant chemotherapy for the treatment of breast cancer is still controversial. MATERIAL AND METHODS: Thirty-one consecutive patients with the diagnosis of invasive breast cancer who received neoadjuvant chemotherapy underwent sentinel lymph node biopsy and complete axillary lymph node dissection. RESULTS: Sentinel lymph nodes were successfully identified in 26 (83.8%) patients. The node was positive for malignancy in nine (34.6%) patients. Two of the patients with a negative sentinel lymph node presented other positive nodes in the final axillary specimen (false negative rate of 18%). CONCLUSIONS: The results obtained by our prospective clinical trial do not support the use of the sentinel lymph node biopsy as an accurate procedure to predict the axillary lymph node status.
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