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  • Title: [The role of alimentary magnesium deficiency in development of nephrolithiasis and its correction with magnesium salts in rats].
    Author: Spasov AA, Iezhitsa IN, Kharitonova MV, Kravchenko MS, Snigur GL.
    Journal: Vopr Pitan; 2008; 77(6):62-71. PubMed ID: 19227867.
    Abstract:
    Aims of our work were to appraise the quantity and nature of renal calcifications and mineral metabolism in the magnesium-deficient rats; and to find out whether the combination of pyridoxine with Mg L-aspartate or Mg chloride will reduce the length of the treatment needed to recover rats from magnesium deficient condition and urolithiasis state. To induce hypomagnesemia, fifty rats were placed on a magnesium-deficient diet (magnesium content < or = 15 mg/kg) and demineralized water for 10 weeks. On the forty-ninth day of magnesium-deficient diet, rats were treated one of the six supplementations: MgCl2, Mg-L-Asp or their combinations with pyridoxine hydrochloride, magnesium sulfate, magne B6.
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