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  • Title: [Prevention and treatment of experimental liver fibrosis in rats by Semen Hoveniae extracts].
    Author: Geng WX, Ding HY, Yi YS.
    Journal: Zhong Yao Cai; 2008 Oct; 31(10):1550-2. PubMed ID: 19230414.
    Abstract:
    OBJECTIVE: To investigate the prevention and treatment of experimental liver fibrosis in rats by Semen Hoveniae extracts (SHE). METHODS: Rats liver fiborsis model was induced by carbon tetrachloride (CCl4). SD rats were randomly divided into six groups: the normal control group, the model control group, the positive control group and the SHE groups. The level of serum procollgan type-III (PC-III), hyaluronic acid (HA), laminin (LN) and liver function were measured, respectively. Liver histological examination was made. RESULTS: SHE could ameliorate CCl4-induced liver fibrosis significantly. The lever of serum PC-III, HA, LN decreased and liver function was improved. The histological examination also demonstrated its anti-fibrotic effect. CONCLUSION: SHE have anti-fibrotic effect on liver in vivo, and may have potential value for clinical use.
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