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  • Title: Synthesis and biological evaluation on novel analogs of 9-methylstreptimidone, an inhibitor of NF-kappaB.
    Author: Ishikawa Y, Tachibana M, Matsui C, Obata R, Umezawa K, Nishiyama S.
    Journal: Bioorg Med Chem Lett; 2009 Mar 15; 19(6):1726-8. PubMed ID: 19231181.
    Abstract:
    Synthesis of 9-methylstreptimidone analogs and their inhibitory activities against NF-kappaB (nuclear factor-kappaB) are reported. Among several active derivatives synthesized in this study, 8 with a relatively simple structure, exhibited inhibitory activity against LPS-induced NO production comparable to that of 9-methylstreptimidone.
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