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  • Title: Antinociceptive effects of 14-membered cyclopeptide alkaloids.
    Author: Trevisan G, Maldaner G, Velloso NA, Sant'Anna Gda S, Ilha V, Velho Gewehr Cde C, Rubin MA, Morel AF, Ferreira J.
    Journal: J Nat Prod; 2009 Apr; 72(4):608-12. PubMed ID: 19231884.
    Abstract:
    The analgesic potential of six 14-membered-ring cyclopeptide alkaloids, namely, franganine (1), discarine B (2), scutianines B (3), C (4), and D (5), and adouetine X (6), have been investigated. Among the compounds tested, only franganine (1) and adouetine X (6) produced antinociceptive effects in a mouse model of acute pain, without inducing undesirable side effects. Furthermore, compound 6 also exhibited a pronounced analgesic effect in a chronic neuropathic pain model in mice. It has been found that adouetine X (6) can decrease the activities of Ca(2+)-ATPase and Na(+)/K(+)-ATPase in vitro. Thus, the present findings have demonstrated that adouetine X (6) is a promising analgesic agent.
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