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  • Title: Synthesis and antibacterial activity of 4'',11-di-O-arylalkylcarbamoyl azithromycin derivatives.
    Author: Ma S, Jiao B, Liu Z, Wang H, Xian R, Zheng M, Lou H.
    Journal: Bioorg Med Chem Lett; 2009 Mar 15; 19(6):1698-701. PubMed ID: 19232491.
    Abstract:
    A series of new 4'',11-di-O-arylalkylcarbamoyl azithromycin derivatives were designed, synthesized and evaluated for their in vitro antibacterial activities. Some derivatives exhibited greatly improved activity against erythromycin-resistant bacteria. Among them, compounds 5f and 5k were found to have potent activity against erythromycin-resistant Streptococcus pneumoniae whose resistance was encoded by the erm or mef gene.
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