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  • Title: The SWI/SNF complex and cancer.
    Author: Reisman D, Glaros S, Thompson EA.
    Journal: Oncogene; 2009 Apr 09; 28(14):1653-68. PubMed ID: 19234488.
    Abstract:
    The mammalian SWI/SNF complexes mediate ATP-dependent chromatin remodeling processes that are critical for differentiation and proliferation. Not surprisingly, loss of SWI/SNF function has been associated with malignant transformation, and a substantial body of evidence indicates that several components of the SWI/SNF complexes function as tumor suppressors. This review summarizes the evidence that underlies this conclusion, with particular emphasis upon the two catalytic subunits of the SWI/SNF complexes, BRM, the mammalian ortholog of SWI2/SNF2 in yeast and brahma in Drosophila, and Brahma-related gene-1 (BRG1).
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