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  • Title: Anti-androgen effects of extracts and compounds from Ganoderma lucidum.
    Author: Liu J, Tamura S, Kurashiki K, Shimizu K, Noda K, Konishi F, Kumamoto S, Kondo R.
    Journal: Chem Biodivers; 2009 Feb; 6(2):231-43. PubMed ID: 19235153.
    Abstract:
    The 30% EtOH extracts of Ganoderma lucidum Fr. Karst (Ganodermateceae) showed weak 5alpha-reductase inhibitory activity and binding ability to androgen receptor. When LNCaP (lymph-node carcinoma of the prostate) cells were treated with the EtOH extracts, cell proliferation was inhibited. Treatment with the extracts significantly inhibited the testosterone-induced growth of the ventral prostate in castrated rats. These results showed that G. lucidum might be a useful ingredient in the treatment of androgen-induced diseases, such as benign prostatic hyperplasia or prostate cancer. From the 30% EtOH extracts, we isolated ganoderiol F, which showed binding activity to androgen receptor and inhibited LNCaP cell proliferation, as one of the active compounds in the 30% EtOH extracts.
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