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  • Title: [Apoptotic protease activating factor 1 inducing apoptosis and related anti-tumor therapy -- review].
    Author: He LL, Sun GZ, Zhang PT.
    Journal: Zhongguo Shi Yan Xue Ye Xue Za Zhi; 2009 Feb; 17(1):251-4. PubMed ID: 19236791.
    Abstract:
    Apoptotic protease activating factor-1 (Apaf1) is an essential factor in intrinsic mitochondrial pathway of apoptosis activation. Apaf1 leads to the formation of apoptosome, which then proteolytically activates caspase-9. The activated caspase-9 opens the downstream signal of caspases to execute programmed cell death. Apaf-1 is important for tumor suppression and drug resistance because it plays a central role in DNA damage-induced apoptosis. Inactivation of the Apaf-1 gene is implicated in disease progression and chemoresistance of some malignancies. Further research on the Apaf-1 will contribute to develop a new type of approach to anti-cancer drugs, which might have good prospect in clinical practice. In this paper, the structure and function of Apaf-1, the mechanism involved in Apaf-1 signaling pathway, and application of Apaf-1 in tumor therapy were reviewed.
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