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  • Title: Design, synthesis, and structure-activity relationship of novel CCR2 antagonists.
    Author: Kothandaraman S, Donnely KL, Butora G, Jiao R, Pasternak A, Morriello GJ, Goble SD, Zhou C, Mills SG, Maccoss M, Vicario PP, Ayala JM, Demartino JA, Struthers M, Cascieri MA, Yang L.
    Journal: Bioorg Med Chem Lett; 2009 Mar 15; 19(6):1830-4. PubMed ID: 19237282.
    Abstract:
    A series of novel 1-aminocyclopentyl-3-carboxyamides incorporating substituted tetrahydropyran moieties have been synthesized and subsequently evaluated for their antagonistic activity against the human CCR2 receptor. Among them analog 59 was found to posses potent antagonistic activity.
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